New therapeutic options for bile acid malabsorption diarrhea
نویسندگان
چکیده
منابع مشابه
Bile Acid Malabsorption/Diarrhoea
Bile acid malabsorption leads to chronic watery, non-bloody diarrhoea. Many patients present with symptoms suggestive of IBS. Idiopathic BAM (no obvious cause) occurs in both men and women, mostly between the ages of 30 and 70. There is often a long history of diarrhoea at the time of diagnosis, sometimes lasting longer than 10 years. The diarrhoea is continuous or intermittent; nocturnal diarr...
متن کاملBile Acid Malabsorption: A Concise Review
Submit Manuscript | http://medcraveonline.com Abbreviations: BAM: Bile Acid Malabsorption; CA: Cholic Acid; CDCA: Chenodeoxycholic Acid; DCA: Deoxycholic Acid; ASBT: Apical Sodium-dependent Bile Acid Transporter; IBS-D: Diarrhea-Predominant Irritable Bowel Syndrome; SeHCAT: Selenium HomotauroCholic Acid Test, FGF: Fibroblast growth factor; GPBAR1: G Protein-coupled Bile Acid Receptor 1; CYP7A1:...
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This study aimed at examining the mechanisms participating in excessive faecal bile acid loss in cystic fibrosis. The study was designed to define the relation between faecal fat and faecal bile acid loss in patients with and without cystic fibrosis related liver disease; to assess terminal ileal bile acid absorption by a seven day whole body retention of selenium labelled homotaurocholic acid ...
متن کاملBile Acid Diarrhea: Prevalence, Pathogenesis, and Therapy
Bile acid diarrhea (BAD) is usually seen in patients with ileal Crohn's disease or ileal resection. However, 25% to 50% of patients with functional diarrhea or diarrhea-predominant irritable bowel syndrome (IBS-D) also have evidence of BAD. It is estimated that 1% of the population may have BAD. The causes of BAD include a deficiency in fibroblast growth factor 19 (FGF-19), a hormone produced i...
متن کاملBiliary lipid composition in idiopathic bile acid malabsorption.
BACKGROUND Chronic diarrhoea is the clinical hallmark of patients presenting with idiopathic bile acid malabsorption. Its pathogenesis is unknown; colonic water secretion can be induced by dihydroxy bile acids, but it is not known whether enrichment of the bile acid pool with these bile acids occurs in such patients. Furthermore, bile acid malabsorption is known to affect biliary lipid composit...
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ژورنال
عنوان ژورنال: Annals of Translational Medicine
سال: 2019
ISSN: 2305-5839,2305-5847
DOI: 10.21037/atm.2019.09.112